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可以看得出来,口服药物的吸收受到人体多个系统的影响,并且受到众多复杂因素的影响。因此,目前用于评估口服药物吸收效果的体外实验方法在研究这一领域时仍面临着显著的局限性。

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研究团队构建了一个数学模型,该模型综合考虑了药物的物理化学属性、胃内液体的流动特性以及药物溶解的动力学过程。利用该模型,研究人员得以模拟并预测药物在胃内受不同姿势影响时的行为模式。

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对于绝大多数药物来说,胃的吸收程度可以忽略不计。药物的主要吸收区域是小肠上段,尤其是十二指肠,因其具备广阔的吸收表面和充足的血液供给。药物分子在小肠中穿过肠壁,进入血液循环,最后通过血液到达目标组织或器官发挥药效。

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